About GMDR

Generalized Multifactor Dimensionality Reduction (GMDR) is a nonparametric and genetic model-free alternative to linear or logistic regression for detecting and characterizing nonlinear interactions among discrete genetic and environmental attributes. Compared with the MDR method (Moore 2004; Ritchie et al. 2001), the GMDR method (Lou et al. 2007) permits adjustment for discrete and quantitative covariates and is applicable to both dichotomous and continuous phenotypes in different population-based study designs. GMDR will increase the precision accuracy and help users draw a more meaningful conclusion.

The GMDR software package was derived from the original MDR software. Our GMDR was designed and developed in an effort to produce an open source tool that would not only allow researchers to use the tool in their research but also provide the flexibility to utilize internal programming resources to extend the tool itself by adding their own GUI or combine it with other methods that they may wish to explore.

GMDR Download

• GMDR0.9.zip (Include applications, examples and results)

Manual

• GMDR User Manual.pdf

Citation:

• Lou XY, Chen GB, Yan L, Ma JZ, Zhu J, Elston RC, and Li MD (2007) A generalized combinatorial approach for detecting gene by gene and gene by environment interactions with application to nicotine dependence. American Journal of Human Genetics 80: 1125-1137. [PMID: 17503330] [PMCID: PMC1867100]
  
  
• Chen GB, Xu Y, Xu HM, Li MD, Zhu J, and Lou XY (2011) Practical and theoretical considerations in study design for detecting gene-gene interactions using MDR and GMDR approaches. PLoS ONE 6:e16981. [PMID: 21386969]

Contact

• Xiang-Yang Lou, Ph.D.
  Section on Statistical Genetics
  Department of Biostatistics
  Ryals Public Health Bldg, 420B
  University of Alabama at Birmingham
  Birmingham, AL 35294
  Phone: (205) 975-9145
  Fax: (205) 975-2541
  E-mail: XLou@ms.soph.uab.edu
  
  
• Guo-Bo Chen, Ph.D.
  Section on Statistical Genetics
  Department of Biostatistics
  Ryals Public Health Bldg, 443D
  University of Alabama at Birmingham
  Birmingham, AL 35294
  Phone: (205) 975-9263
  Fax: (205) 975-2540
  E-mail: bchen@ms.soph.uab.edu